Endocrine Abstracts

Thyroid hormones have been employed for 3 decades as adjunct treatments in depression and the stabilization of manic depression, especially in women. After a brief historical review, two studies will be presented to highlight this 'drug' use of thyroid hormone.(1) A meta analysis of six studies on the use of thyroid hormone to accelerate antidepressant response. Five studies found T3 to be significantly more effective than placebo, especially in women....

Background: Hypothyroidism may profoundly alter mental function and influence mood and cognition, but the neural correlates of these impairments and of thyroid hormone treatment are not well understood.Methods: We prospectively studied 24 subjects, 14 previously untreated newly diagnosed hypothyroid patients (age 42±12 yrs; 11 female, 3 men) and 10 euthyroid control subjects (41±12 yrs). All patients underwent comprehensive neuropsychiatric ass...